GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9902453 | 1 | rs56280226 | chr17:28429575 | TP53I13 | chr17:27895739-27900174:+ | 0.19 | 5.21 | 2.88E-7 | Coffee consumption (cups per day) |
| THCA | cis | rs73201462 | 1 | rs56287882 | chr3:128030343 | EEFSEC | chr3:127872313-128127488:+ | -0.22 | -3.87 | 0.000123 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs2243480 | 1 | rs56291018 | chr7:65390339 | CCT6P1 | chr7:65216092-65228661:+ | 0.41 | 6.41 | 3.44E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs56291018 | chr7:65390339 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.95 | 9.06E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs56291018 | chr7:65390339 | RABGEF1 | chr7:66093890-66276446:+ | 0.53 | 6.46 | 2.51E-10 | Diabetic kidney disease |
| THCA | cis | rs7960483 | 1 | rs56295584 | chr12:45931742 | LOC400027 | chr12:46119810-46121530:- | 0.12 | 3.35 | 0.000867 | Hypertension |
| THCA | cis | rs41997 | 1 | rs56295991 | chr7:118196744 | ANKRD7 | chr7:117864712-117882782:+ | 0.23 | 3.78 | 0.000173 | Response to platinum-based chemotherapy in non-small-cell lung cancer |
| THCA | cis | rs4664308 | 1 | rs56297666 | chr2:160902023 | LY75 | chr2:160625141-160761262:- | 0.21 | 4.84 | 1.74E-6 | Idiopathic membranous nephropathy |
| THCA | cis | rs6088813 | 1 | rs56306402 | chr20:33937704 | CPNE1 | chr20:34213968-34262539:- | 0.3 | 5.88 | 7.84E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs56306402 | chr20:33937704 | GDF5 | chr20:33897002-34042568:- | -0.17 | -3.74 | 0.000207 | Height |
| THCA | cis | rs6088813 | 1 | rs56306402 | chr20:33937704 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.18 | 3.81E-22 | Height |
| THCA | cis | rs3772130 | 1 | rs56314138 | chr3:121356656 | IQCB1 | chr3:121488610-121553926:- | 0.53 | 10.23 | 2.43E-22 | Cognitive performance |
| THCA | cis | rs728616 | 1 | rs56317427 | chr10:81861934 | MBL1P | chr10:81664654-81710783:+ | 0.35 | 5.41 | 9.95E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THCA | cis | rs728616 | 1 | rs56317427 | chr10:81861934 | PLAC9 | chr10:81892258-81904784:+ | -0.23 | -4.95 | 1.03E-6 | Chronic obstructive pulmonary disease-related biomarkers |
| THCA | cis | rs728616 | 1 | rs56317427 | chr10:81861934 | SFTPD | chr10:81697498-81708861:- | 0.27 | 3.4 | 0.000733 | Chronic obstructive pulmonary disease-related biomarkers |